![]() ![]() Other Medications and Supplements: Summary of Results, by Agent (KQ 4 and 5)ĮTable 7. AChEIs and Memantine: Summary of Results, by Medication Type (KQ 4 and 5)ĮTable 6. Trial and Population Characteristics: Summary Across All Intervention Types (KQ 4 and 5)ĮTable 5. Study and Population Characteristics of Included Diagnostic Accuracy Studies (KQ 2)ĮTable 4. Study Design-Specific Quality Rating Criteria*ĮTable 3. Literature Search Strategies for Primary LiteratureĮTable 2. Publication type: Ancillary study to excluded primary study.ĮMethods. Quality: Study did not meet criteria for fair or good quality. Study design: Not an included study design comparative effectiveness follow-up less than 3 months (does not apply to harms) case-control design (KQ2 only) cohort or case-control (with n<1000) (KQ5 only). Intervention: Study used an excluded intervention or screening approach or intervention aim irrelevant. Population: Study population not relevant (age <65 years exclusively populations with mental health illnesses or chronic disease severe dementia professional caregivers otherwise not representative community-dwelling population). Outcomes: Study did not report relevant outcomes. Setting: Study was not conducted in a country relevant to US practice or study was conducted in intermediate care facility or otherwise unrepresentative setting. Healthy control mild cognitive impairment Alzheimer’s disease Alzheimer’s disease neuroimaging initiative Mini-Mental State Examination Montreal Cognitive Assessment apolipoprotein E early mild cognitive impairment late mild cognitive impairment.AArticles could be assessed for more than 1 KQ.īReasons for exclusion: Aim: Study aim not relevant. In addition, the measurements of MMSE and MoCA are moderately correlated for the follow-up visits. MMSE and MoCA are comparable as cognitive assessment tools to monitor cognitive changes. At last, the MMSE scores were moderately related to MoCA scores, which got stronger along with the time of follow-up. For participants with a diagnosis of LMCI, the cognitive performance deteriorated in a linear manner 12 months after the baseline, which was independent of MMSE or MoCA. By contrast, the MoCA scores were not significantly different between HC and EMCI groups at either baseline or any of the follow-up visits. The MMSE scores were significantly different among the four groups at baseline, which was true for each of the three annual follow-up visits. For those participants who had both MMSE and MoCA assessments done, a Pearson correlation analysis was performed between the two assessments for each visit. MMSE or MoCA scores were compared among the four groups using an analysis of variance (ANOVA) model with repeated measures with post-hoc Bonferroni correction. Our goal was to assess their efficacy for monitoring cognitive changes, as well as the correlation between the two tests.Īt baseline, participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) were divided into four groups based on their cognitive diagnoses: healthy control (HC), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI), and Alzheimer's disease (AD). Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are two commonly used cognitive screening and diagnostic tools.
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